Hronic disorder course/chronic only diagnostic test results pathology bx/bone biopsy/abnormal x-ray xray/epiphysis lesions/site associated diseases & rule outs associated disease & complications cold autoimmune hemolytic anemia histiocytoma, malignant fibrous disease mechanism & classification class class/soft tissue involvement class/bone disorder (ex) class/skeletal (category) pathophysiology pathophysiology/histiocyte/macrophage disorder (ex) process process/neoplastic (category) process/sarcoma/site lymph node mets/predilection process/sarcoma/site retroperitoneum/mesentery predilection synonyms synonym fibrous histiocytoma malignant, fibrous histiocytoma malignant (morphologic abnormality), fibrous histiocytomas malignant, fibroxanthoma malignant, fibroxanthosarcoma, fibroxanthosarcoma (morphologic abnormality), histiocytoma malignant fibrous, histiocytomas malignant fibrous, malignant fibrous histiocytoma, malignant fibrous histiocytoma of soft tissue, malignant fibrous histiocytoma of the soft tissue, malignant fibrous histiocytoma stage unspecified, malignant fibrous histiocytomas, malignant fibroxanthoma, mfh, synonym/fibroxanthosarcoma, synonym/malignant histiocytoma/fibrous/bone definition primary malignant bone tumors are rare; four types make up the majority; malignant fibrous histiocytoma (mfh) - a pleomorphic sarcoma of storiform pattern without differentiation; osteosarcoma - similar to malignant fibrous histiocytoma with differentiation to osteoid production; osteosarcoma - cellular cartilaginous lesion with abundant binucleate cells, myxoid areas, and pushing borders; ewing sarcoma - small, blue-round cell neoplasm; genetics: ewing sarcoma has 11/22 chromosomal translocation and ew5-fli-1 fusion protein; osteosarcomas shows loss of retinoblastoma and p53 suppressor genes and amplification of the genes c-myc, mdm-2, sas, and cyclin-dependent kinase;prevalence in usa: rare: 5000 bone and soft tissue sarcomas per year, a practicing orthopedic surgeon may see one primary malignant tumor of bone in every five years of practice; ewing sarcoma is less common in blacks; age:mfh - teens and elderly. buy viagra online cheap generic viagra cheap viagra viagra for sale viagra for sale buy viagra

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